Myocardial work as an independent predictor of postoperative NT-proBNP after transcatether aortic valve replacement

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): SUPPORTED BY THE ÚNKP-22-3-I NEW NATIONAL EXCELLENCE PROGRAM OF MINISTRY FOR CULTURE AND INNOVATION FROM SOURCE RESEARCH, DEVELOPMENT FUND. Introduction Aortic valve stenosis is one the most prevalent valvular disease with significant clinical burden. Its treatment has been revolutionized by transcatether aortic replacement (TAVR). Left ventricular function key element preprocedural patient assessment, however, conventional echocardiographic parameters are substantially influenced increased afterload associated disease. Myocardial work index a novel parameter that quantifies myocardial deformation in context concomitant left pressure, therefore, it may be reliable measure contractility even afterload. Purpose Our aim was to evaluate TAVR patients using and index, examine their association characteristics patients. Methods 84 candidates were enrolled (age 79±6 years; 48% female). Conventional advanced measurements performed prior procedure at 12 months as part follow-up visit. We measured ejection fraction (EF), also global longitudinal strain (GLS) speckle-tracking echocardiography, then volume curves estimated from systolic blood pressure mean transaortic gradient, we quantified (GWI). Detailed medical history, symptomatic status marker congestion, NT-proBNP levels obtained. Results EF did not change significantly (53±13 vs. 55±10 %; p = 0.172), while absolute value GLS (−13.5±4.5 −15.3±3.6 p<0.001). GWI decreased (1914±787 1666±594 mmHg%; 0.001) compared values (Figure 1). reduced cohort (1057 [586–3037] 627 pg/mL [376–1198]; Using multivariate regression analysis, examining relevant parameters, presence atrial fibrillation (β=0.31; p<0.01), (β=-0.32; p<0.01) proved independent predictors postprocedural (R²=0.30; Conclusions In our study population changed after procedure. The during follow-up. Accordingly, help improvement selection estimation prognosis this complex population.